Biosynthesis of glycosylphosphatidylinositol is essential to the survival of the protozoan parasite Toxoplasma gondii.

نویسندگان

  • Michael J Wichroski
  • Gary E Ward
چکیده

The PIGA gene from Toxoplasma gondii has been cloned and characterized. Like mammalian PIGA, the transmembrane and C-terminal domains are sufficient to direct localization to the parasite endoplasmic reticulum. A functional copy of PIGA is required for tachyzoite viability, demonstrating that glycosylphosphatidylinositol biosynthesis is an essential process in T. gondii.

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عنوان ژورنال:
  • Eukaryotic cell

دوره 2 5  شماره 

صفحات  -

تاریخ انتشار 2003